Interleukin-1 signaling and CD4⁺ T cells control B cell recruitment to the lungs in chronic beryllium disease.

ABSTRACT: Chronic beryllium disease (CBD) is a debilitating pulmonary disorder that occurs due to persistent exposure to beryllium (Be) particles in the workplace. Be-exposure causes activation of the innate immune system, resulting in the secretion of interleukins and chemokines that drive the accumulation of B and T cells in the lungs. However, the mechanisms by which innate molecules influence the recruitment of B cells and B cell-mediated protection in CBD are poorly understood. In this study, we employed multiple approaches to examine the role of innate immune signaling and CD4⁺ T cells in B cell recruitment and function in the lungs. We show that the absence or blocking of IL-1R1 signaling prevents the recruitment of B cells to the lungs of BeO-exposed mice. Additionally, we show th

SUBMITTER: Gaballa JM 

PROVIDER: S-EPMC11810750 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature