Exploring the Axis of Gut Microbiota-Inflammatory Cytokine-Atrial Fibrillation in the Pathogenesis of Atrial Fibrillation.

ABSTRACT: A relationship may exist between the gut microbiota, inflammatory factors and atrial fibrillation (AF); however, the precise biological mechanisms linking these components remain uncertain.In this study, 211 single-nucleotide polymorphisms associated with the gut microbiota were collected from the MiBioGen consortium. Summary data for AF were sourced from large-scale genome-wide association studies. Two-step Mendelian randomization (MR) was applied to estimate the possible mediating effect of inflammatory cytokines on the causality between the gut microbiota and AF. MR confirmed the effects of class Lentisphaeria, family Bifidobacteriaceae, family XIII, genus Anaerostipes, genus Howardella, genus Intestinibacter, genus Lachnospiraceae (NK4A136 group), genus Odoribacter, genus Ruminococcus

SUBMITTER: Chen J 

PROVIDER: S-EPMC11810809 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature