Engineering dual-driven pro-angiogenic nanozyme based on porous silicon for synergistic acceleration of burn infected wound healing.

ABSTRACT: The high mortality risk of burn infected wounds has dictated the clinical need for the development of new biomaterials that can regulate multiple aspects of the healing process in a high-quality manner. Although nanozymes have made progress in inflammation modulation and antibacterial management, they often lack the ability in pro-angiogenesis, which greatly limits their functional application in the synergistic treatment of burn infected wounds. In this study, a smart pro-angiogenic nanozyme is simply and efficiently synthesized by in situ reduction of Pt precursors on porous silicon (PSi) nanocarriers. Owing to the hybridization of Pt, the Pt-decorated PSi (Pt@PSi) nanocomposites exhibit excellent near-infrared (NIR) photothermal activity and peroxidase-like catalytic activity, wh

SUBMITTER: Duan W 

PROVIDER: S-EPMC11810849 | biostudies-literature | 2025 Apr

REPOSITORIES: biostudies-literature