SLPI controls neutrophil migration abilities and impacts neutrophil skin infiltration in experimental psoriasis.

ABSTRACT: Skin infiltration by neutrophils is a hallmark of the chronic inflammatory skin disease psoriasis, yet the mechanisms underlying neutrophil recruitment and positioning in chronically inflamed skin remain poorly understood. In this study, we demonstrate the significant impact of a total genetic deficiency of secretory leukocyte protease inhibitor (SLPI) on neutrophil migration in mouse skin. Without SLPI, neutrophils displayed an unconventional migratory pattern, characterized by altered interactions with vessel walls and reduced efficiency in extravasating from blood vessels into skin tissue during the early stages of experimental psoriasis. This was associated with changes in tissue motility, positioning neutrophils farther from the skin entry vessels and closer to the skin surface. Neutr

SUBMITTER: Kwiecinska P 

PROVIDER: S-EPMC11810868 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature