Genetic diversity and transmission pattern of multidrug-resistant tuberculosis based on whole-genome sequencing in Wuhan, China.

ABSTRACT:

Background

Investigating the molecular epidemiological characteristics of multidrug-resistant tuberculosis (MDR-TB) in China's moderate-burden regions, such as Wuhan, is crucial for understanding and controlling disease transmission.

Materials and methods

This study analyzed MDR-TB isolates from pulmonary tuberculosis cases registered at Wuhan Pulmonary Hospital in 2017. Whole genome sequencing (WGS) was used to identify resistance-conferring mutations, examine their associations with specific Mycobacterium tuberculosis lineages or sublineages, and assess clustering profiles.

Results

Among the 149 analyzed strains, the most prevalent mutations associated with resistance to 11 anti-tuberculosis drugs were identified as follows: rpoB Ser450Leu (59.73%, rif

SUBMITTER: Wei L 

PROVIDER: S-EPMC11810889 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature