High-fat diet promotes gestational diabetes mellitus through modulating gut microbiota and bile acid metabolism.

ABSTRACT:

Introduction

Gestational diabetes mellitus (GDM) is a condition characterized by glucose intolerance during pregnancy, estimated to affect approximately 20% of the whole pregnancies and is increasing in prevalence globally. However, there is still a big gap in knowledge about the association between gut microbiota associated metabolism alterations and GDM development.

Methods

All the participants accomplished the validated internet-based dietary questionnaire for Chinese and serum, fecal samples were collected. HFD, control diet or colesevelam intervention was fed to GDM mice models or Fxr-/- mice models, with or without antibiotics cocktail treatment. Fecal microbiota transplantation were used for further validation. Gut microbiota and metabolites were detected by metagenom

SUBMITTER: Yao L 

PROVIDER: S-EPMC11810896 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature