Vitamin A family suppresses periodontitis by restoring mitochondrial metabolic reprogramming in macrophages through JAK-STAT pathway.

ABSTRACT:

Objective

Mitochondrial metabolic reprogramming in macrophages is crucial in the development and progression of inflammation. Given vitamin A's antioxidant properties and its therapeutic effects on inflammation, this study aims to elucidate how vitamin A influences mitochondrial metabolic reprogramming in inflammatory states, specifically in periodontitis, through genetic bioinformatics and experimental methods.

Method

The study utilized the GSE16134 dataset from the Gene Expression Omnibus (GEO) database, focusing on human periodontitis. Vitamin A-targeted genes (ATGs) were identified and analyzed using CIBERSORT to explore their role in inflammation. Cluster analysis revealed two phenotypes associated with ATGs, showing differential expression of genes like COX1, IL-1β<

SUBMITTER: Cheng Z 

PROVIDER: S-EPMC11810908 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature