BMP9 induces postnatal zonal stratification of immature articular cartilage through reconfiguration of the existing collagen framework.

ABSTRACT: Articular cartilage lines bones in synovial joints, and its main structural element, collagen, has an arcade-like arrangement formed from an initially random network in a process called postnatal maturation. This reshaping of the extracellular matrix is similar across all species and is critical for the lifelong strength and durability of cartilage. Collagen remodelling during maturation is difficult to study because it spans a period of time between birth and puberty, and in larger animals this can be months or years. In this study, we show that growth factor bone morphogenetic protein-9 (BMP9) induces collagen remodelling in intact immature articular cartilage explants within 21 days, generating the characteristic arcade-like structure and zonal anisotropic architecture of adult cartilag

SUBMITTER: Anderson-Watters M 

PROVIDER: S-EPMC11810917 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature