Saussurea costus alleviates ulcerative colitis by regulating the gut microbiota and improving intestinal barrier integrity.

ABSTRACT:

Introduction

The global health challenge of ulcerative colitis (UC) has been classified by the WHO as a modern refractory disease, commonly referred to as green cancer, with limited treatment options still available, highlighting the urgent need for the development of new therapeutic strategies. Recent pharmacological research has shown that traditional Chinese medicine saussurea costus (SC) possesses beneficial antibacterial and anti-inflammatory properties. Nevertheless, its underlying mechanism remains elusive.

Methods

Firstly, we identified the main active components of SC through UHPLC-QTOF-MS analysis. Subsequently, UC mice were induced using DSS and administered different doses of SC to evaluate its efficacy. Additionally, the impact of SC on the repair of the intesti

SUBMITTER: Pang WL 

PROVIDER: S-EPMC11810970 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature