IL-33 signaling is dispensable for the IL-10-induced enhancement of mast cell responses during food allergy.

ABSTRACT:

Background

The IL-33/ST2 axis plays a pivotal role in the development of IgE-mediated mast cell (MC) responses during food allergy. We recently demonstrated that the pleiotropic cytokine, IL-10, not only exerts proinflammatory effects on IgE-mediated MC activation, but also promotes IL-33-induced MC responses. However, whether IL-33 is necessary for IL-10's proinflammatory effects has not been examined.

Methods

To therefore determine the role of the IL-33/ST2 axis in this pathway, we assessed the effects of IL-10 on IgE-mediated MC activation and food allergy development in wild-type (WT) and ST2^-/- mice.

Results

IL-10 stimulation significantly enhanced IL-33 gene expression, ST2 receptor expression, cytokine production, mMCP-1 secretion, and proliferation

SUBMITTER: Krajewski D 

PROVIDER: S-EPMC11810977 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature