Ca_V2.3 channels in the mouse central medial thalamic nucleus are essential for thalamocortical oscillations and spike wave discharges.

ABSTRACT: Voltage-gated calcium channels are important for thalamocortical (TC) oscillations related to spike-wave discharges (SWDs) during absence seizures. The role of Ca_V2.3 R-type channels expressed in the thalamic intralaminar complex in SWDs, however, is not well studied. We investigated pharmacologically induced SWDs from the central medial thalamus (CMT) and somatosensory cortex in a Ca_V2.3 knockout (KO) mouse model using local field potential (LFP), and electroencephalographic (EEG) recordings. The duration of cumulative SWDs was significantly decreased in Ca_V2.3 KO mice compared with wild-type (WT) mice. A characteristic increase in the delta and theta waves was observed in both the CMT and somatosensory cortex during SWDs with delta (1-4 Hz) band TC synchr

SUBMITTER: Tadic VP 

PROVIDER: S-EPMC11811020 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature