The spectrum-efficacy correlation of Kai-Xin-San for cognition of Aβ₄₂ transgenic <i>Drosophila</i> and verification of its active ingredients.

ABSTRACT:

Introduction

This study aims to establish the fingerprint spectra of Kai-Xin-San (KXS) and investigate its spectrum-effect relationship in treating Alzheimer's disease (AD).

Methods

Initially, the fingerprints of 15 batches of KXS were established and analyzed using HPLC, with the method's precision, stability, and repeatability thoroughly evaluated. Subsequently, the effects of the 15 batches of KXS were assessed in an olfactory escape memory experiment, utilizing Aβ₄₂ transgenic drosophila as a model. Finally, the spectrum-effect relationship between the KXS fingerprint and memory improvement was analyzed, with the active ingredients subjected to validation testing.

Results

The results identified seventeen common peaks in the fingerprint, and eight

SUBMITTER: Wu J 

PROVIDER: S-EPMC11811076 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature