One lung ventilation during thoracoscopic lobectomy alters lung microbiome miversity and composition.

ABSTRACT: Current research indicates that the lungs are not sterile and maintain their own unique microecological balance, which can be disrupted by mechanical ventilation.One-lung ventilation (OLV) induces ischemia-reperfusion (IR) injury in the non-ventilated lung, a common contributor to acute lung injury during the perioperative period. This study investigates alterations in the pulmonary microbiome following one-lung ventilation during thoracoscopic lobectomy and evaluates the impact of differential microbiota on inflammatory responses. Approved by the Hospital Ethics Committee, this study involved 65 patients undergoing thoracoscopic lobectomy from April 2024 to June 2024. An internally controlled paired analysis was implemented to compare bronchoalveolar lavage fluid(BALF) collected from the

SUBMITTER: Ruijiao Z 

PROVIDER: S-EPMC11811219 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature