CD45RO-Positive Memory T-Cell Density in the Tumoral Core and Invasive Margin Predict Long-Term Survival in Esophageal Squamous Cell Carcinoma.

ABSTRACT:

Background

The association between tumor-infiltrating lymphocytes and tumor immunity has long been recognized. Among T-cell types, CD45RO-positive memory T cells (CD45RO⁺) are reported to correlate with survival in several cancer types, but clinical evidence is lacking in esophageal squamous cell carcinoma (ESCC).

Methods

In surgical specimens from 162 preoperatively untreated patients, immunohistochemistry for CD45RO was performed to evaluate the density of CD45RO⁺ in the tumor core (CT) and invasive margin (IM) using an auto-count method. Patients were classified into high- versus low-CD45RO⁺ groups based on CD45RO⁺ density in CT and IM separately and combined. The relationship between CD45RO⁺ density and clinicopathol

SUBMITTER: Noma T 

PROVIDER: S-EPMC11811247 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature