A Multi-omic study integrating plasma protein, multiple tissues, and single-cell identifies RNASET2 as a key gene for lung cancer.

ABSTRACT:

Introduction

Lung cancer (LC) has the highest cancer-related mortality rate. Even though genome-wide association studies (GWAS) have identified numerous loci linked to LC risk, the underlying causal genes and biological processes are still mostly unknown.

Methods

The LC GWAS summary data comprised 29,863 cases and 55,586 controls of European ancestry. The weight file and related files of plasma protein, multi-tissue, and single-cell were obtained from Zhang's study, Mancuso lab, and Thompson's study, respectively. We conducted transcriptome association studies (TWAS) employing functional Summary-based Imputation (FUSION) from two levels, which were multiple tissues and single cell. We conducted proteome-wide association studies (PWAS) from plasma protein. Conditional and joi

SUBMITTER: Shi J 

PROVIDER: S-EPMC11811349 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature