DPH2 is a biomarker associated with cell death, immunity and prognosis based on pan-cancer analysis.

ABSTRACT:

Objective

DPH2, also known as DPH2L2, is one of two human genes similar to yeast dph2. One DPH2 variant has been linked to diphthamide syndrome, a disorder affecting ribosome function. While studies on DPH2 in a single cancer type have been documented, no comprehensive investigations of DPH2 across pan-cancer have been reported, its role in tumor pathogenesis and development remains unclear.

Methods

The predictive significance and immune and biological roles of DPH2 in 33 different cancer types were investigated. We conducted a comprehensive analysis of DPH2 in pan-cancer using various bioinformatics tools, including expression, prognosis, its association with immune infiltration, cell death, methylation, and many other aspects. In addition, qRT-PCR and immunohistochemistry

SUBMITTER: Xiao M 

PROVIDER: S-EPMC11811350 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature