A cycle of complications: a case report on trastuzumab-induced takotsubo cardiomyopathy causing left ventricular thrombosis complicated by thromboembolic stroke.

ABSTRACT:

Background

Left ventricular thrombus (LVT) formation is an uncommon phenomenon, typically observed in acute cardiac settings and hypercoagulable states. Takotsubo cardiomyopathy (TC) is a reversible condition originally thought to be linked to immense emotional stress. The occurrence of chemotherapy-related cardiotoxicity presenting with TC and LVT formation is a relatively new concept that remains not fully understood.

Case summary

We present the case of a 77-year-old woman with Stage IV breast cancer being treated with trastuzumab and capecitabine therapy, who presented to our hospital with symptoms of right-sided weakness, facial droop, and slurred speech. She was admitted for acute left frontal lobe infarction due to an occluded distal left posterior M2 branch of the lef

SUBMITTER: Patel V 

PROVIDER: S-EPMC11811414 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature