Survival Impacts of Mitochondrial Status in Esophageal Squamous Cell Carcinoma Patients.

ABSTRACT:

Background

Little is known about the survival impacts of mitochondrial status in esophageal squamous cell carcinoma (ESCC) patients who undergo neoadjuvant chemotherapy (NAC) followed by surgery.

Methods

In total, 260 pre-NAC samples from ESCC patients were analyzed. Mitochondrial status was estimated employing an objective, immunohistochemistry-based system (Mito-score). Mito-scores were dichotomized according to the median value of our cohort. We also evaluated the immune microenvironment (CD4, CD8, Foxp3, HLA class-1, Ki-67 and programmed death ligand-1) on pre-NAC specimens. Multivariate Cox hazards models were applied to determine independent predictors of poor overall survival (OS).

Results

Patients with cT3-4 tumors had higher Mito-scores than those with cT1-2

SUBMITTER: Sugawara K 

PROVIDER: S-EPMC11811432 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature