Diagnostic performance of 2-[¹⁸F]FDG PET/CT in recurrent differentiated thyroid cancer and elevated antithyroglobulin antibodies: an updated systematic review and bivariate meta-analysis.

ABSTRACT:

Purpose

This updated systematic review and bivariate meta-analysis aimed to investigate the diagnostic performance of 2-[¹⁸F]FDG PET/CT for the detection of recurrent disease in patients with differentiated thyroid cancer (DTC) who have negative ¹³¹I whole body scintigraphy and increased antithyroglobulin antibodies (TgAb) levels.

Methods

The current systematic review was carried out following a preset protocol, and the "Preferred Reporting Items for a Systematic Review and Meta-Analysis" served as a guideline for its development and reporting. A comprehensive research of the PubMed/MEDLINE, Embase and Cochrane library databases was conducted until June 2024.

Results

Between 2002 and 2023, 13 studies (608 patients) published on this topic were se

SUBMITTER: Albano D 

PROVIDER: S-EPMC11811433 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature