Survival Outcomes and Genetic Characteristics of Resected Pancreatic Acinar Cell Carcinoma.

ABSTRACT:

Background

Pancreatic acinar cell carcinoma (pACC) is a rare neoplasm of the exocrine pancreas. There is a dearth of information about tumor characteristics and patient outcomes. This study describes the clinical characteristics, genetic alterations, and survival outcomes of resected pACC.

Patients and methods

Consecutive patients undergoing pancreatectomy for pathologically confirmed pACC from 1999 to 2022 across three high-volume pancreas surgery centers were analyzed. Patient demographics, tumor characteristics, treatment data, and genetic sequencing were obtained through retrospective abstraction.

Results

A total of 61 patients with resected pACC were identified. Median overall survival (OS) was 73 months and median recurrence free survival was 22 months. Nine pat

SUBMITTER: Blair AB 

PROVIDER: S-EPMC11811437 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature