The Inflammatory Landscape of a Whole-Tissue Explant Model of Hidradenitis Suppurativa.

ABSTRACT: Hidradenitis suppurativa (HS) is a relatively common and highly morbid inflammatory skin disease. Due to the relatively limited understanding of HS's pathogenesis, there are currently insufficient treatment options available, and many patients' medical needs are not being met. This is partly due to the historical scarcity of ex vivo assays and animal models that accurately recapitulate the disease. Thus, we have developed a standardised whole-tissue explant model of HS to examine its pathogenic mechanisms and the efficacy of potential treatments within intact human tissue. We measured cytokine protein and RNA within whole tissue maintained in an agar-media solution, finding that IL-6 and IL-8 concentrations trended upwards in both HS explants and healthy controls, while IL-17A, IL-1β, and

SUBMITTER: Leboit PE 

PROVIDER: S-EPMC11811487 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature