Co-existing regeneration mechanisms in severe alcohol-related steatohepatitis.

ABSTRACT:

Background

Keratin 7 positive (K7⁺) cells are considered to be activated in case of impaired hepatocyte replication. Their exact role and their interaction with hepatocytes and macrophages also implicated in liver regeneration remain poorly characterized in humans. The aim of this study is to evaluate hepatocyte, K7⁺ cells and macrophage populations in severe alcohol-related steatohepatitis (sASH) and to link them with liver injury and patients' outcomes.

Methods

Immunohistochemical and morphometric studies for total K7⁺ cells, macrophages (CD68⁺ cells), proliferative hepatocytes (Ki67⁺ hepatocytes) and proliferative K7⁺ cells (double K7⁺ and Ki67⁺) were performed on liver biopsies of pat

SUBMITTER: Lejeune A 

PROVIDER: S-EPMC11811559 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature