Enhancing the management of acute and gangrenous cholecystitis: a systematic review supported by the TriNetX database.

ABSTRACT:

Background

Acute cholecystitis (AC) leads to emergency hospital admissions, and is categorized into mild, moderate, or severe grades, and affects hospital stay, surgery rates, costs, and prognosis. Gangrenous cholecystitis (GC) is the severe form and entails gallbladder wall necrosis and infection, possibly leading to emphysematous cholecystitis (EC), a life-threatening variant: early recognition of such a condition is crucial, since its symptoms may mimic uncomplicated AC. The current literature lacks comprehensive reviews on EC and GC due to their rarity and this study aims to bridge this gap by utilizing the TriNetX database, comparing clinical data of AC with GC outcomes.

Methods

The study involved data retrieval from PubMed and Medline and the TriNetX database. Initiall

SUBMITTER: Fabbri N 

PROVIDER: S-EPMC11811563 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature