Acute Administration of 10 mg Methylphenidate on Cognitive Performance and Visual Scanning in Healthy Adults: Randomised, Double-Blind, Placebo-Controlled Study.

ABSTRACT:

Objective

To examine the effect of a low dose (10 mg) of methylphenidate on cognitive performance, visuospatial working memory (VSWM) and gaze behaviour capabilities in healthy adults.

Methods

This randomised, double-blind, placebo-controlled and crossover study examined the effects of 10 mg methylphenidate on cognitive performance, VSWM and gaze behaviour. Fixation duration and rate, gaze transition entropy, and stationary gaze entropy were used to quantify visual scanning efficiency in 25 healthy adults (36% female, mean ± SD age = 33.5 ± 7.8 years, BMI = 24.1 ± 2.9 kg/m²). Attention, memory, and reaction time were assessed using the E-CogPro test battery.

Results

Methylphenidate significantly enhanced performance in numeric working memory tasks, reflecte

SUBMITTER: Aitken B 

PROVIDER: S-EPMC11811595 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature