Bioactive sorbicillinoid derivatives from an endophytic fungus Trichoderma citrinoviride.

ABSTRACT: Three new sorbicillinoid derivatives, citrinsorbicillinol A-C (1-3), along with three known compounds, such as trichosorbicillin G (4), dibutyl phthalate (5), and 3-(4-methoxyphenyl) propanoic acid (6), were isolated from the endophyte Trichoderma citrinoviride of Coptis chinensis. Their structures were elucidated through extensive analyses of spectroscopic data, computer-assisted structure elucidation (ACD/Structure Elucidator), density functional theory (DFT) calculations of the nuclear magnetic resonance (NMR) spectra, and electronic circular dichroism (ECD). Biologically, compounds 1-4 exhibited potential antioxidant activity, as assessed using the 1,1-diphenyl-2-picrylhydrazyl (DPPH) assay, with IC₅₀ values rang

SUBMITTER: Xia YP 

PROVIDER: S-EPMC11811624 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature