Methanolation of Olefins: Low-Pressure Synthesis of Alcohols by the Formal Addition of Methanol to Olefins.

ABSTRACT: Methanolation of olefins is introduced as a new low-pressure synthetic pathway to C1 elongated alcohols. Formally, H₃COH is added to the C=C bond in a 100 % atom efficient manner. Mechanistically, the overall transformation occurs as a tandem reaction sequence by combining the dehydrogenation of methanol to syngas at a CO : H₂ ratio of 1 : 2 with subsequent hydroformylation to the corresponding aldehyde and its final hydrogenation to the alcohol. The dehydrogenation and hydrogenation steps are catalyzed by a Mn/pincer complex, while the hydroformylation is accomplished by a Rh/phosphine catalyst. Using 1-octene as prototypical substrate, a yield of 80 % nonanol was achieved with a ratio of 93 : 7 of linear to branched alcohols and turnover numbers (TON_Rh) o

SUBMITTER: Stahl S 

PROVIDER: S-EPMC11811677 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature