Self-Assembly and Biological Properties of Highly Fluorinated Oligonucleotide Amphiphiles.

ABSTRACT: Nucleic acids, used as therapeutics to silence disease-related genes, offer significant advantages over small molecule drugs: they provide high specificity, the ability to target "undruggable" molecules, and adaptability to a wide range of disease phenotypes. However, their instability in biological media, as well their rapid clearance from the organism limit their applicability, necessitating the use of nanocarriers to overcome these challenges. Among these strategies, spherical nucleic acids (SNA)-composed of a densely packed corona of oligonucleotides around a nanoparticle-have emerged as a powerful tool, in particular when self-assembled from DNA amphiphiles. This non-covalent strategy however has caveats, especially when it comes to stability in complex biological media, where these S

SUBMITTER: Laurent Q 

PROVIDER: S-EPMC11811686 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature