Construction of the Single-Cell Landscape of Hashimoto's Thyroiditis Tissue and Peripheral Blood by Single-Cell RNA Sequencing.

ABSTRACT:

Background

Hashimoto's thyroiditis (HT) is the most common organ-specific autoimmune disease, and its etiology may be related to genetic, environmental, and epigenetic factors. However, its exact pathogenesis remains elusive.

Methods

In this study, single-cell transcriptomic sequencing and bioinformatics analysis were performed on the thyroid tissues of six HT patients, peripheral blood mononuclear cells (PBMCs) of four HT patients, and normal thyroid tissue of one healthy control. A panoramic single-cell atlas of HT was constructed to explore changes in the abundance of different cell subsets in the states of the disease.

Results

A single-cell atlas of HT was constructed, and eight cell types were defined based on the marker genes. Subsequent clustering analysis of T

SUBMITTER: Song K 

PROVIDER: S-EPMC11811715 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature