Multiple Ion Charge Extraction (MICE) for High-Throughput Charge Detection Mass Spectrometry.

ABSTRACT: Charge detection mass spectrometry (CD-MS) is a single-particle technique, where the masses of individual ions are determined from simultaneous measurements of their mass-to-charge ratio (m/z) and charge. The ions are trapped in an electrostatic linear ion trap (ELIT) and oscillate back and forth through a conducting cylinder connected to a charge-sensitive amplifier. The oscillating ions generate a periodic signal that is processed with fast Fourier transforms (FFTs) to obtain the oscillation frequency (which is related to m/z) and magnitude (which is proportional to the charge). The simultaneous trapping of two or more ions is a way to increase throughput. However, when multiple ions are trapped, it is possible that some of them have overlapping oscillation fr

SUBMITTER: Parikh RA 

PROVIDER: S-EPMC11811880 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature