Age-Specific Functional Connectivity Changes After Partial Sleep Deprivation Are Correlated With Neurocognitive and Molecular Signatures.

ABSTRACT:

Background

This study aimed to investigate age-specific alterations in functional connectivity after sleep deprivation (SD) and decode brain functional changes from neurocognitive and transcriptomic perspectives.

Methods

Here, we examined changes in global and regional graph measures, particularly regional network strength (RNS), in 41 young participants and 36 older participants with normal sleep and after 3 h of SD. Additionally, by utilizing cognitive probabilistic maps from Neurosynth and gene expression data from the Allen Human Brain Atlas, we applied partial least-squares regression analysis to identify the neurocognitive and transcriptional correlates of these RNS changes.

Results

After SD, older participants exhibited decreased RNS in the default mode network

SUBMITTER: Yu L 

PROVIDER: S-EPMC11811888 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature