Acoustic hologram-induced virtual in vivo enhanced waveguide (AH-VIEW).

ABSTRACT: Optical imaging and phototherapy in deep tissues face notable challenges due to light scattering. We use encoded acoustic holograms to generate three-dimensional acoustic fields within the target medium, enabling instantaneous and robust modulation of the volumetric refractive index, thereby noninvasively controlling the trajectory of light. Through this approach, we achieved a remarkable 24.3% increase in tissue heating rate in vitro photothermal effect tests on porcine skin. In vivo photoacoustic imaging of mouse brain vasculature exhibits an improved signal-to-noise ratio through the intact scalp and skull. These findings demonstrate that our strategy can effectively suppress light scattering in complex biological tissues by inducing low-angle scattering, achieving an effective depth re

SUBMITTER: Lin Q 

PROVIDER: S-EPMC11811914 | biostudies-literature | 2024 Feb

REPOSITORIES: biostudies-literature