Effect of HBeAg/anti-HBe coexistence on HBeAg seroconversion in treatment-naive chronic hepatitis B patients with peginterferon-α.

ABSTRACT:

Background

As an uncommon serological pattern, the effect of hepatitis B e antigen/anti-hepatitis B e (HBeAg/anti-HBe) coexistence on peginterferon-α (Peg-IFN-α) therapy in patients with chronic hepatitis B (CHB) remains unknown. Moreover, Peg-IFN-α is clinically limited due to several side effects. It is of significant value to early identify the favored population for Peg-IFN-α therapy in CHB patients.

Objectives

This study aimed to analyze the impact of HBeAg/anti-HBe coexistence on the effectiveness of Peg-IFN-α and to construct a nomogram for predicting the occurrence of HBeAg seroconversion in treatment-naïve CHB patients with Peg-IFN-α therapy.

Design

Retrospective, case-control study of treatment-naïve CHB patients with Peg-IFN-α at a tertiary care center.

SUBMITTER: Song K 

PROVIDER: S-EPMC11811962 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature