Olink Profiling of Intestinal Tissue Identifies Novel Biomarkers For Colorectal Cancer.

ABSTRACT: Comprehensive protein profiling in intestinal tissues provides detailed information about the pathogenesis of colorectal cancer (CRC). This study quantified the expression levels of 92 oncology-related proteins in tumors, paired para-carcinoma tissues, and remote normal tissues from a cohort of 52 CRC patients utilizing the Olink technology. The proteomic profile of normal tissues closely resembled that of para-carcinoma tissues while distinctly differing from that of tumors. Among the 68 differentially expressed proteins (DEPs) identified between the tumor and normal tissues, WISP-1, ESM-1, and TFPI-2 showed the most pronounced alterations and exhibited relatively strong correlations. These markers also presented the highest AUC values for distinguishing between tissue types. Bioinformati

SUBMITTER: Xiao C 

PROVIDER: S-EPMC11812010 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature