Multicomponent Electrosynthesis of Enaminyl Sulfonates Starting from Alkylamines, SO₂, and Alcohols.

ABSTRACT: An electrochemical one-pot synthesis of enaminyl sulfonate esters was established, featuring a quasidivided cell under constant current conditions. The multicomponent reaction utilizes simple and readily available alkylamines and an easy-to-use stock solution of SO₂ and alcohols. Omission of additional supporting electrolyte through in-situ-generated monoalkylsulfite facilitates the downstream processing. A diverse scope with more than 28 examples and yields up to 85% as well as a 20-fold scale-up reaction prove the feasibility of this novel protocol.

SUBMITTER: Breitschaft FA 

PROVIDER: S-EPMC11812012 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature