Detoxome Capacity of the Adult Rumen Fluke <i>Calicophoron daubneyi</i> Extends into Its Secreted Extracellular Vesicles.

ABSTRACT: Helminth parasites have long adapted to survive hostile host environments and can likely adapt against the chemical anthelmintic challenge. One proposed adaptation route is via Phase I and II xenobiotic metabolizing enzymes (XMEs). For successful Helminth pharmacotherapy discovery programs, a working understanding of Helminth-derived chemical detoxification, the Helminth detoxome, is a must. At present, the detoxome of a newly emerging Helminth parasite, the rumen fluke Calicophoron daubneyi, remains unexplored. Thus, a combined bioinformatics, sub-, and global-proteomic approach has been employed to examine the detoxome of adult C. daubneyi. Transcriptome analysis revealed a complement of Phase I (cytochrome P450s and monoamine oxygenases) and Phase II (glutathione transfera

SUBMITTER: Allen NR 

PROVIDER: S-EPMC11812014 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature