Cognitive phenotypes: Unraveling the heterogeneity in cognitive dysfunction among patients with primary brain tumors receiving radiotherapy.

ABSTRACT:

Background

Patients with primary brain tumors demonstrate heterogeneous patterns of cognitive dysfunction, which we explore using latent profile analysis to identify cognitive phenotypes and their trajectories in patients receiving radiotherapy (RT).

Methods

Ninety-six patients completed neuropsychological testing before and post-RT (3, 6, and 12 months) on a prospective longitudinal trial, including measures of processing speed, executive function, language, and verbal and visual memory. Models with 2-4 classes were examined. Demographic and clinical data were examined across phenotypes and post-RT cognitive change was evaluated.

Results

The optimal model identified 3 unique cognitive phenotypes including a group of patients with generalized impairments (11.5%), a gr

SUBMITTER: Reyes A 

PROVIDER: S-EPMC11812028 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature