The Janus face of Bifidobacterium in the development of atopic eczema: A role for compositional maturation.

ABSTRACT:

Background

Atopic eczema often develops in the first year of life, when the composition of the gut microbiota is most plastic as illustrated by the decrease in bifidobacteria after weaning. This may provide the opportunity for microbial stimuli and their environmental determinants to alter the disease course.

Objectives

To determine the role of the genus Bifidobacterium for atopic eczema in early childhood.

Methods

We analysed the bacterial composition in fecal samples of 618 children of the PASTURE ("Protection against Allergy-Study in Rural Environments") birth cohort using 16S rRNA amplicon sequencing of fecal samples collected at 2 and 12 months of age. Atopic eczema was defined as a parent-reported doctor's diagnosis until 2 years, and patterns of rash symptoms w

SUBMITTER: Depner M 

PROVIDER: S-EPMC11812080 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature