Deep Saliva Proteomics Elucidating the Pathogenesis of Early Childhood Caries and Identifying Biomarkers for Early Prediction.

ABSTRACT: Early childhood caries (ECC) significantly impacts the physical and mental health of children. Saliva stands as a critical model for investigating the pathogenesis of caries disease since it reflects both host and microbial dynamics. However, the specific contributions of salivary host factors to ECC have not been fully understood. In this study, we monitored a prospective cohort of 3-4 year-old healthy children for 12 months, who either stayed caries-free or developed caries. Deep quantitative proteomics analysis of saliva was conducted at both recruitment and end point of the cohort to investigate the molecular mechanisms underlying ECC etiology and identify potential biomarkers for caries prediction. Proteomics analysis identified a total of 2873 proteins and revealed involvement of imm

SUBMITTER: Huang S 

PROVIDER: S-EPMC11812083 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature