Cognitive markers for the distinction between asymptomatic and prodromal Alzheimer's disease in Down syndrome: Correlations with volumetric brain changes.

ABSTRACT:

Introduction

Motivated by the difficulties in detecting cognitive deterioration in the context of Down syndrome (DS), we aimed to identify markers of prodromal Alzheimer's disease (AD) in this population.

Methods

Sixty-two participants with DS (age > 45) distributed in three groups (asymptomatic [A_DS], prodromal [P_DS], and dementia [D_DS]) completed the Cambridge Examination for Mental Disorders of Older People with Down's Syndrome and Others with Intellectual Disabilities, Cambridge Cognitive Examination for older adults with Down's Syndrome, and Barcelona Test for Intellectual Disability tests and a magnetic resonance imaging scan.

Results

Although temporal orientation showed significant differences among groups, only a predictive dia

SUBMITTER: Garcia-Alba J 

PROVIDER: S-EPMC11812121 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature