Validity of one-time assessments for identifying prodromal Alzheimer's disease in adults with Down syndrome.

ABSTRACT:

Introduction

New Alzheimer's disease (AD) treatments have created an urgent need for accurate early diagnosis of high-risk adults with Down syndrome (DS), distinguishing prodromal DS-AD symptoms from lifelong cognitive impairments. Often, clinicians will need to evaluate dementia status during a single assessment, and here we describe empirically supported methods effective under such circumstances.

Methods

Archived data collected between 1987 and 2017 included longitudinal findings for 144 individuals maintaining cognitive stability and 126 developing prodromal DS-AD. Response operating characteristic analyses compared groups, defined by the presence/absence of prodromal DS-AD, for a single assessment.

Results

Groups differed on all measures without adjusting for dev

SUBMITTER: Krinsky-McHale SJ 

PROVIDER: S-EPMC11812125 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature