Diabetes mellitus exacerbates changes in white matter hyperintensity shapes and volume: A longitudinal study.

ABSTRACT:

Introduction

Although white matter hyperintensity (WMH) can progress over time, little is known about the underlying mechanisms. In addition, type 2 diabetes mellitus (T2DM) exacerbates the accumulation of WMH. Here we aimed to investigate longitudinal changes in WMH shapes and volume in older adults with and without T2DM.

Methods

Participants underwent baseline and follow-up magnetic resonance imaging (MRI). WMH volume and shape markers were automatically assessed. We compared WMH volume and shape markers at baseline and follow-up.

Results

A total of 200 participants were included at baseline and 181 at follow-up. The mean age ± SD of our study participants was 69.86 ± 6.03 years; 79 (39.90%) had a history of diabetes mellitus (T2DM) and 73 (36.50%) were male. For sh

SUBMITTER: Xu S 

PROVIDER: S-EPMC11812126 | biostudies-literature | 2025 Jan-Mar

REPOSITORIES: biostudies-literature