Genome-wide characterization of circular RNAs in three rat models of pulmonary hypertension reveals distinct pathological patterns.

ABSTRACT:

Background

Pulmonary hypertension (PH) is a devastating disease marked by elevated pulmonary artery pressure, resulting in right ventricular (RV) failure and mortality. Despite the identification of several dysregulated genes in PH, the involvement of circular RNAs (circRNAs), a subset of long noncoding RNAs, remains largely unknown.

Methods

In this study, high-throughput RNA sequencing was performed to analyze the genome-wide expression patterns of circRNAs in pulmonary arteries from three models of PH rats induced by hypoxia (Hyp), hypoxia/Sugen5416 (HySu), and monocrotaline (MCT). Differentially expressed circRNAs (DEcircRNAs) were identified, and a weighted gene coexpression network was constructed to explore circRNA networks associated with PH pathogenesis. A circRNA-mi

SUBMITTER: Fu G 

PROVIDER: S-EPMC11812181 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature