Understanding depression in autism: the role of subjective perception and anterior cingulate cortex volume.

ABSTRACT:

Background

The prevalence of depression is elevated in individuals with autism spectrum disorder (ASD) compared to the general population, yet the reasons for this disparity remain unclear. While social deficits central to ASD may contribute to depression, it is uncertain whether social interaction behavior themselves or individuals' introspection about their social behaviors are more impactful. Although the anterior cingulate cortex (ACC) is frequently implicated in ASD, depression, and social functioning, it is unknown if it explains differences between ASD adults with and without co-occurring depression.

Methods

The present study contrasted observed vs. subjective perception of autism symptoms and social interaction assessed with both standardized measures and a lab task,

SUBMITTER: Hao Y 

PROVIDER: S-EPMC11812218 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature