A computational framework to optimize the mechanical behavior of synthetic vascular grafts.

ABSTRACT: The failure of synthetic small-diameter vascular grafts has been attributed to a mismatch in the compliance between the graft and native artery, driving mechanisms that promote thrombosis and neointimal hyperplasia. Additionally, the buckling of grafts results in large deformations that can lead to device failure. Although design features can be added to lessen the buckling potential (e.g., reinforcing coil), the addition is detrimental to decreasing compliance. Herein, we developed a novel finite element (FE) framework to inform vascular graft design by evaluating compliance and resistance to buckling. A batch-processing scheme iterated across the multi-dimensional design parameter space, which included three parameters: coil thickness, modulus, and spacing - generating 100 unique designs

SUBMITTER: Jiang D 

PROVIDER: S-EPMC11812276 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature