Religion, spirituality, and DNA methylation in HPA-axis genes among Hispanic/Latino adults.

ABSTRACT:

Aim

Investigate associations between religion and spirituality (R&S) and DNA methylation of four HPA-axis genes (i.e. 14 CpG sites) among 992 adults from the Hispanic Community Health Study/Study of Latinos cohorts.

Methods

We assessed 1) the association between R&S measures and mean percent methylation overall and stratified by nativity status (US-born or immigrant) and 2) if interactions between R&S and methylation differed by nativity status.

Results

Among individuals with the FKBP5 CC genotype, increased spirituality scores were associated with significantly lower methylation levels among immigrants, compared to US-born participants. Organizational religiosity (e.g. service attendance) was associated with increased FKBP5 (CC genotype) methylation amo

SUBMITTER: Zhen-Duan J 

PROVIDER: S-EPMC11812325 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature