Dual functional nanoplatforms potentiate osteosarcoma immunotherapy via microenvironment modulation.

ABSTRACT: Osteosarcoma (OS), a highly aggressive bone tumor, presents significant challenges in terms of effective treatment. We identified that cellular autophagy was impaired within OS by comparing clinical OS samples through bioinformatic analyses and further validated the inhibition of mitochondrial autophagy in OS at the transcriptomic level. Based on this finding, we investigated the therapeutic potential of a dual functional metal nanoplatform (MnS_x) to facilitate a transition from the protective effect of low-level autophagy in OS to the killing effect of high-level autophagy in OS. MnS_x facilitated intracellular H₂S generation via endocytosis, leading to the S-sulfhydration of ubiquitin-specific peptidase 8 (USP8) and subsequent promotion of mitochondrial au

SUBMITTER: Lu S 

PROVIDER: S-EPMC11812574 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature