Dynamic global acetylation remodeling during the yeast heat shock response.

ABSTRACT: All organisms experience stress and must rapidly respond to changing conditions. Thus, cells have evolved sophisticated rapid-response mechanisms such as post-translational protein modification to rapidly and reversibly modulate protein activity. One such post-translational modification is reversible lysine acetylation, where proteomic studies have identified thousands of acetylated proteins across diverse organisms. While the sheer size of the 'acetylome' is striking, the function of acetylation for the vast majority of proteins remains largely obscure. Here, we show that global acetylation plays a previously unappreciated role in the heat shock response of Saccharomyces cerevisiae. We find that dysregulated acetylation renders cells heat sensitive, and moreover, that the acetylome

SUBMITTER: Hardman-Kavanaugh RE 

PROVIDER: S-EPMC11812598 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature