Apical periodontitis microbiome association with salivary and serum inflammatory burden.

ABSTRACT:

Aims

Apical Periodontitis (AP) involves complex interactions between the root canal microbiome and the host immune response, with potential risk of local and systemic inflammatory burden, however there is no evidence available regarding correlation between microbiome and inflammatory marker levels. This study aims to identify the microbiome of saliva, intracanal and blood samples in AP subjects and investigate the correlation between intracanal and blood microbiomes with serum inflammatory biomarker levels, and salivary microbiomes with salivary inflammatory biomarker levels.

Methodology

Saliva, Intracanal and blood samples were collected from AP patients undergoing root canal retreatment. Following DNA extraction, 16SrRNA gene-sequence analysis (V1-V2) was performed using I

SUBMITTER: Bakhsh A 

PROVIDER: S-EPMC11812624 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature