Identification of diagnostic biomarkers related to the efferocytosis pathway and immune cell infiltration characteristics in pediatric sepsis by bioinformatics analysis.

ABSTRACT: Pediatric sepsis is a serious disease characterized by multiple organ failure. Due to its unique pathogenesis, its clinical mortality rate is very high. This study systematically evaluated the value of efferocytosis related genes in the diagnosis of sepsis in children. We downloaded gene expression profiles related to pediatric sepsis from the gene expression omnibus database, identify differentially expressed genes (DEGs) by limma R package, and retrieve adult sepsis gene expression profiles to determine the specificity of pediatric sepsis biomarkers. Selected pediatric sepsis specific genes from these profiles and used clusterProfiler for Kyoto Encyclopedia of Genes and Genomes (KEGG), gene ontology, and Reactome databases for functional enrichment. Genesets related to Efferocytosis was

SUBMITTER: Guo L 

PROVIDER: S-EPMC11813005 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature