Association of Obesity With Sedative Dosing, Sedative Response, and Clinical Outcomes in Mechanically Ventilated Critically Ill Children.

ABSTRACT:

Objectives

This study aimed to investigate the impact of obesity on the use of analgesics and sedatives, rates of iatrogenic withdrawal syndrome (IWS), and outcomes in mechanically ventilated pediatric patients. Additionally, it sought to assess whether a nurse-implemented sedation protocol would be equally effective for children with and without obesity.

Design

Secondary analysis of the Randomized Evaluation of Sedation Titration for Respiratory Failure (RESTORE) pediatric multicenter clinical trial.

Setting

Thirty-one U.S. PICUs.

Patients

Children 1-17 years old, categorized as with or without obesity according to World Health Organization and Centers for Disease Control and Prevention criteria.

Interventions

None.

Measurements and main results

SUBMITTER: Ward SL 

PROVIDER: S-EPMC11813009 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature